Overview

This is the analysis of white matter dsi studio connectometry for Loop clousre position error

Methods

Participants

  • Total number of scans = 120 (males and females)

  • Total scans used in analysis= 118

  • Excluded subs 329 and 372 from analyses due to bad behavior data and Subject 347 failed quality control check in DSI

  • Several subjects removed because they did not have rad3 score

Subject numbers for Loop closure task

  • Rad 3
    • All subjects: 38
    • Men: 14
    • Women: 24
    • Stage:
      • Pre: 10
      • Peri: 7
      • Post: 7
  • Average
    • All subjects: 42
    • Men: 17
    • Women: 25
    • Stage:
      • Pre: 11
      • Peri: 7
      • Post: 7

Scan parameters

  • Locations from UCSB and UCI

QSIprep

  • Version used: 0.16.0RC3

  • The following parameters were used

    • dwi_denoise_window 5
    • hmc_model 3dSHORE
    • hmc-transform Rigid
    • shoreline_iters 2
      DSI Studio

  • Version and tags used via singularity container: chen-2022-07-31

  • Parameters

    • T-threshold = 2.5
    • Length = 25
    • Permutation = 4,000
    • pruning 4
    • non normalized QA

Connectronomy analysis methods write up

A diffusion spectrum imaging scheme was used, and a total of 128 diffusion sampling were acquired.The maximum b-value was 4990 s/mm². The in-plane resolution was 1.8 mm. The slice thickness was 1.8 mm. The accuracy of b-table orientation was examined by comparing fiber orientations with those of a population-averaged template (Yeh et al. Neuroimage, 2018). The b-table was flipped by. The diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction (Yeh et al., Neuroimage, 58(1):91-9, 2011) to obtain the spin distribution function (Yeh et al., IEEE TMI, ;29(9):1626-35, 2010). A diffusion sampling length ratio of 1.25 was used. The output resolution in diffeomorphic reconstruction was 1.8 mm isotropic. The tensor metrics were calculated using DWI with b-value lower than 1750 s/mm². The quantitative anisotropy was extracted as the local connectome fingerprint (LCF, Yeh et al. PLoS Comput Biol 12(11): e1005203) and used in the connectometry analysis.

Diffusion MRI connectometry (Yeh et al. NeuroImage 125 (2016): 162-171) was used to derive the correlational tractography that has QA, MD, AD, and RD correlated with Maze Accuracy and Loop variables. A nonparametric Spearman partial correlation was used to derive the correlation, and the effect of sex, age_scan_years, and repo_status was removed using a multiple regression model. The total number of subjects varied on analysis (See Analyses and Final sample sizes above). A T-score threshold of 2.5 was assigned and tracked using a deterministic fiber tracking algorithm (Yeh et al. PLoS ONE 8(11): e80713, 2013) to obtain correlational tractography. A seeding region was placed at whole brain (39,49,29) .

The tracks were filtered by topology-informed pruning (Yeh et al. Neurotherapeutics, 16(1), 52-58, 2019) with 4 iteration(s). A length threshold of 25 voxel distance was used to select tracks. To estimate the false discovery rate, a total of 4000 randomized permutations were applied to the group label to obtain the null distribution of the track length.




Behavior

Degrees traveled is the total degrees traveled that the participant took to reach the start position. Participants who indicated the correct location completed a total of 360 degrees. Participants were tested on three different sizes of circles: Radius 1m, 2m, and 3m. For white matter analysis we used the data from radius 3 and an average of performance on all three circle sizes. The average position error on the 1m circle is 342.273315. The average position error on the 2m circle is 367.9252881. The average position error on the 3m circle is 368.75375. The average position error across all sizes is 360.2293738.

There are were significant differences in performance between men and women on the rad3 loop (t test, p= 0.0076377) and on the average of all circles ( p = 0.0295558). The mean distance for degrees traveled in men on the rad3 circle was 328.1449, and in women it was 392.4422458. Men undershot the target location while women overshot the location The mean for the average of all circles in men is 338.1785059 and women is 375.223964.

The average for degrees traveled on rad3
pre = 368.69367 peri = 453.99765 post = 377.1886

The average for degrees traveled on average of all circles
pre = 368.69367 peri = 453.99765 post = 377.1886





Loop Degrees traveled Rad3

QA

All subjects

Positive Correlations (FDR = 0.180868)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 349 55.4126 9.42135 3863
Uncinate_Fasciculus_R 184 58.7509 6.40167 1891
Superior_Longitudinal_Fasciculus2_R 119 55.8072 6.37801 1783
Inferior_Fronto_Occipital_Fasciculus_R 92 56.7042 5.57865 1386
Arcuate_Fasciculus_R 62 59.1987 5.14341 1230
Cingulum_Frontal_Parietal_R 53 54.9946 5.08536 1117
Inferior_Fronto_Occipital_Fasciculus_L 21 54.4779 3.14423 423
Uncinate_Fasciculus_L 19 55.2715 2.81094 343
Parietal_Aslant_Tract_R 10 52.3993 2.84455 333



Negative Correlations (FDR = 0.047850)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 283 57.4049 9.01854 3667
Corpus_Callosum_Tapetum 121 52.1369 8.19499 2750
Cerebellum_L 117 53.9887 5.7971 1425
Corpus_Callosum_Forceps_Major 78 54.8541 5.76128 1430
Optic_Radiation_L 46 53.2267 3.98842 665
Corticospinal_Tract_R 40 56.5032 4.67283 969
Inferior_Fronto_Occipital_Fasciculus_L 33 53.162 3.64915 556
Cingulum_Frontal_Parietal_R 29 54.1488 4.09454 713
Fornix_R 24 53.3508 3.44746 498
Fornix_L 22 53.2924 3.03286 385
Anterior_Commissure 13 52.7817 2.70355 303
Middle_Cerebellar_Peduncle 13 51.3942 3.22569 420
Inferior_Longitudinal_Fasciculus_L 10 50.9979 2.87904 332



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop degree error rad3


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop degree error rad3


Glass Brain displaying tracts that had QA positively and negatively correlated with loop degree error rad3







Men

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.212234)

Not significant

Women

Positive Correlations (FDR = 0.000325)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 1021 57.9318 12.7012 7340
Inferior_Fronto_Occipital_Fasciculus_R 429 61.3108 7.68513 2844
Uncinate_Fasciculus_R 318 59.9901 7.56301 2695
Superior_Longitudinal_Fasciculus2_R 129 56.4331 5.96302 1576
Arcuate_Fasciculus_R 95 61.5436 5.56326 1496
Cingulum_Frontal_Parietal_R 89 55.2862 5.40176 1267
Inferior_Fronto_Occipital_Fasciculus_L 45 54.7178 4.0903 719
Cingulum_Frontal_Parahippocampal_R 16 54.8773 3.48678 524



Negative Correlations (FDR = 0.002141)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 128 60.4652 5.94958 1681
Corpus_Callosum_Forceps_Major 67 58.4558 5.09541 1192
Corpus_Callosum_Tapetum 58 52.351 6.75475 1876
Cerebellum_L 55 53.1324 4.62077 891



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop degree error rad3 in women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop degree error rad3 in women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop degree error rad3 in women







pre

Positive Correlations (FDR = 0.020756)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 1071 59.5768 12.8688 7749
Inferior_Fronto_Occipital_Fasciculus_R 803 63.7896 9.82581 4837
Superior_Longitudinal_Fasciculus2_R 456 56.5196 9.74207 4213
Uncinate_Fasciculus_R 241 59.2559 6.83784 2176
Cingulum_Frontal_Parietal_R 176 59.6144 5.44274 1387
Middle_Cerebellar_Peduncle 172 56.3814 8.25146 3015
Arcuate_Fasciculus_R 125 58.7911 6.78069 2123
Corpus_Callosum_Forceps_Major 99 60.6149 6.59084 2068
Superior_Longitudinal_Fasciculus3_R 97 58.1526 6.27604 1799
Corticospinal_Tract_L 95 57.5871 6.95848 2190
Inferior_Fronto_Occipital_Fasciculus_L 93 55.3226 6.67853 1938
Corpus_Callosum_Body 83 55.3082 7.41598 2389
Arcuate_Fasciculus_L 77 57.8102 5.93626 1600
Corticospinal_Tract_R 74 58.9253 5.58196 1442
Cingulum_Parolfactory_R 72 65.1761 4.11311 866
Corpus_Callosum_Tapetum 53 53.2914 5.71911 1369
Reticular_Tract_R 28 59.0082 3.5891 597
Superior_Longitudinal_Fasciculus2_L 27 53.9315 4.0594 698
Thalamic_Radiation_Anterior_R 27 52.5299 4.02383 668
Medial_Lemniscus_L 21 56.2021 3.87557 663
Uncinate_Fasciculus_L 17 57.6619 2.94957 394
Anterior_Commissure 16 52.7544 3.17624 418
Cingulum_Frontal_Parietal_L 15 53.2061 2.25769 213
Frontal_Aslant_Tract_R 13 52.4662 3.40944 479
Inferior_Longitudinal_Fasciculus_R 12 53.5031 3.17275 423
Corticostriatal_Tract_Anterior_L 11 53.0968 2.85955 341



Negative Correlations (FDR = 0.067453)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 215 55.9956 9.05757 3608
Cerebellum_L 189 54.535 7.92195 2688
Corpus_Callosum_Forceps_Major 162 59.9477 6.22928 1827
Corpus_Callosum_Body 144 56.6362 7.15624 2278
Fornix_L 39 61.5921 4.44318 955
Vermis 16 51.6353 3.54623 510
Cingulum_Frontal_Parietal_L 11 54.5484 2.70725 314
Medial_Lemniscus_R 11 55.637 2.52229 278



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop degree error rad3


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop degree error rad3


Glass Brain displaying tracts that had QA positively and negatively correlated with loop degree error rad3







peri

Positive Correlations (FDR = 0.751698)

No significant correlations



Negative Correlations (FDR = 0.067830)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 662 64.3498 18.7758 17817
Cerebellum_L 355 55.6881 15.2368 10154
Cerebellum_R 289 54.4109 14.4872 8969
Middle_Cerebellar_Peduncle 213 61.1463 12.1779 7122
Inferior_Fronto_Occipital_Fasciculus_R 209 61.6887 11.3058 6193
Corpus_Callosum_Forceps_Major 179 60.8784 12.0207 6909
Corpus_Callosum_Tapetum 170 61.5825 11.6983 6619
Corpus_Callosum_Forceps_Minor 143 59.9763 10.8438 5539
Arcuate_Fasciculus_L 140 58.5826 10.522 5094
Arcuate_Fasciculus_R 118 67.0445 8.90221 4173
Corticospinal_Tract_L 108 60.5047 9.44033 4235
Superior_Longitudinal_Fasciculus2_R 107 62.5326 8.67849 3699
Inferior_Longitudinal_Fasciculus_R 105 60.2169 9.75552 4501
Inferior_Longitudinal_Fasciculus_L 99 61.7253 8.55852 3551
Inferior_Fronto_Occipital_Fasciculus_L 98 62.4148 8.60408 3629
Cingulum_Frontal_Parietal_R 87 64.3309 7.09724 2545
Dentatorubrothalamic_Tract_L 83 57.2363 9.27004 3863
Cingulum_Frontal_Parietal_L 76 59.6695 6.80313 2169
Frontal_Aslant_Tract_L 74 61.6571 8.36071 3385
Superior_Longitudinal_Fasciculus2_L 71 60.1783 8.42523 3355
Corticostriatal_Tract_Posterior_L 69 62.5321 8.44667 3504
Corticospinal_Tract_R 68 64.367 7.9908 3228
Corticostriatal_Tract_Superior_L 61 55.9756 7.96204 2787
Medial_Lemniscus_L 57 58.2948 6.64226 2020
Corticostriatal_Tract_Posterior_R 48 60.4274 7.57603 2724
Optic_Radiation_L 41 56.2988 5.34238 1262
Dentatorubrothalamic_Tract_R 40 57.6617 6.77383 2078
Cingulum_Parahippocampal_Parietal_R 37 56.8785 5.38414 1295
Cingulum_Parolfactory_R 34 63.5997 4.4855 1005
Medial_Lemniscus_R 31 62.6518 5.5725 1528
Corticostriatal_Tract_Superior_R 28 57.8696 5.78868 1523
Thalamic_Radiation_Posterior_R 28 59.2231 5.56598 1441
Cingulum_Parolfactory_L 27 56.1484 2.85718 360
Corticopontine_Tract_Parietal_L 26 66.5467 5.2087 1418
Extreme_Capsule_L 25 58.6456 4.73573 1033
Thalamic_Radiation_Posterior_L 23 56.0896 5.42396 1296
Fornix_L 23 55.6651 4.04688 716
Superior_Longitudinal_Fasciculus3_R 20 61.1053 4.43038 942
Vermis 20 56.207 4.6706 963
Anterior_Commissure 18 66.8917 4.34754 993
Uncinate_Fasciculus_L 17 58.8176 3.52805 575
Extreme_Capsule_R 16 55.2609 4.11799 736
Corticopontine_Tract_Parietal_R 15 66.4311 4.47964 1047
Thalamic_Radiation_Superior_L 15 53.2275 3.85108 620
Parietal_Aslant_Tract_L 13 55.253 3.93808 673
Fornix_R 13 70.47 2.96022 485
Superior_Longitudinal_Fasciculus3_L 12 58.1728 3.87487 686
Superior_Longitudinal_Fasciculus1_R 11 65.2688 3.87064 768
Uncinate_Fasciculus_R 11 62.9109 3.18745 502
Thalamic_Radiation_Anterior_R 11 59.6429 3.7365 654
Middle_Longitudinal_Fasciculus_L 10 55.8239 3.57068 559
Middle_Longitudinal_Fasciculus_R 10 56.4026 3.77715 632
Reticular_Tract_L 10 61.8136 3.59947 629



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop degree error rad3 in peri-menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop degree error rad3 in peri-menopausal women







post

Positive Correlations(FDR = 1.000000)

No significant correlations



Negative Correlations (FDR = 0.354664)

No significant correlations







Peri + Post

Positive Correlations(FDR = 0.009696)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 1622 63.902 18.3067 16820
Corpus_Callosum_Forceps_Minor 1404 59.763 15.887 11847
Corpus_Callosum_Forceps_Major 806 66.387 12.7898 8529
Corpus_Callosum_Tapetum 560 61.5853 13.2782 8528
Corticospinal_Tract_R 509 60.9721 9.7636 4565
Cingulum_Frontal_Parietal_R 415 60.5383 8.49103 3428
Medial_Lemniscus_R 306 58.1572 9.80472 4391
Inferior_Fronto_Occipital_Fasciculus_R 198 57.7676 7.69138 2684
Arcuate_Fasciculus_R 155 59.5448 8.13774 3097
Middle_Cerebellar_Peduncle 142 54.264 7.42721 2351
Uncinate_Fasciculus_R 131 61.076 6.272 1887
Dentatorubrothalamic_Tract_R 107 57.6358 8.41308 3204
Thalamic_Radiation_Anterior_R 98 58.79 6.01037 1668
Superior_Longitudinal_Fasciculus1_R 97 57.6798 6.10963 1691
Corticostriatal_Tract_Posterior_R 83 55.5504 7.81849 2667
Cingulum_Parolfactory_R 77 60.4195 5.14267 1255
Corticopontine_Tract_Parietal_R 75 60.7556 7.30308 2545
Parietal_Aslant_Tract_R 62 56.5647 4.92369 1077
Cingulum_Frontal_Parahippocampal_R 56 57.0471 4.63608 963
Cingulum_Frontal_Parietal_L 56 56.0541 5.23606 1207
Superior_Longitudinal_Fasciculus2_L 54 59.3435 5.03377 1181
Thalamic_Radiation_Posterior_R 44 60.4682 4.86923 1126
Corticostriatal_Tract_Anterior_R 42 53.5792 5.6703 1353
Superior_Longitudinal_Fasciculus2_R 35 53.4432 5.1494 1113
Corticostriatal_Tract_Superior_R 35 57.2057 5.20238 1216
Arcuate_Fasciculus_L 32 59.2593 5.1969 1257
Frontal_Aslant_Tract_L 30 56.5996 3.58085 570
Reticular_Tract_R 29 58.6385 4.82235 1071
Inferior_Fronto_Occipital_Fasciculus_L 28 66.5794 4.13017 892
Cingulum_Parahippocampal_Parietal_R 23 56.5219 3.65489 593
Middle_Longitudinal_Fasciculus_L 23 55.1418 3.53111 540
Extreme_Capsule_L 18 60.5783 4.04637 779
Corticostriatal_Tract_Anterior_L 18 53.4413 3.26705 448
Extreme_Capsule_R 16 59.888 4.15493 812
Inferior_Longitudinal_Fasciculus_R 15 53.6198 3.59742 545
Superior_Longitudinal_Fasciculus1_L 15 59.7427 3.12425 458
Corticostriatal_Tract_Posterior_L 15 57.2292 3.8028 650
Corticopontine_Tract_Frontal_R 13 54.4597 3.28654 462
Corticostriatal_Tract_Superior_L 13 52.6233 3.82282 604
Cingulum_Parolfactory_L 12 51.6763 2.82105 323
Inferior_Longitudinal_Fasciculus_L 12 57.345 3.68624 612
Corticospinal_Tract_L 12 53.8482 3.34426 473
Anterior_Commissure 12 55.8474 2.39216 251
Fornix_R 11 53.4689 3.02392 384
Corticopontine_Tract_Occipital_R 10 53.2044 2.54193 270



Negative Correlations (FDR = 0.099355)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 135 54.3717 7.15637 2187
Cerebellum_R 100 53.7922 8.01642 2715
Middle_Cerebellar_Peduncle 30 53.9386 3.95605 663
Cingulum_Parolfactory_L 25 57.371 2.46144 273
Arcuate_Fasciculus_L 18 53.9059 3.54814 533
Corpus_Callosum_Body 13 53.546 3.70407 577
Cingulum_Frontal_Parietal_L 10 54.2132 2.18349 203



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop degree error rad3


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop degree error rad3


Glass Brain displaying tracts that had QA positively and negatively correlated with loop degree error rad3







Summary of Results

For all subjects, Degree error was correlated with QA values with age and sex marked as covariates. Tracts with QA values were both positively and negatively correlated with DE performance. When analyzed by sex, Men displayed tracts that were significantly negatively correlated with DE, DSI found no tracts positively correlated with DE (FDR=1.00). DSI studio found that tracts with QA in women displayed both positive and negative associations with DE performance. Women were further analyzed by menopause stage. Pre-menopause women displayed positive and negative relationships between tracts with QA and DE performance. DSI sutdio found that peri-menopause women displayed significant negative correlations between tracts with QA and DE and there were not significant positive correlations ( FDR= 0.7516098). Women in post menopause displayed no significant positive or negtive correlations (FDR= 1.000, 0.354664, respectively). When peri and post menopause women were grouped together, tracts with QA were positively and negatively correlated with DE performance







MD

Summary of Results

Tracts with MD were positively correlated with DE performance when all subjects were analyzed. In men, there were no significantly correlated tracts associated with DE performance. In women, tracts with MD were positively associated with DE performance. Pre-menopause women displayed MD tracts with significantly positively correlations to DE. Peri and Post -menopause women displayed significantly negative relationships between MD and DE performance when analyzed seperately. When analyzed together, tracts were positively correlated with DE.







All Subjects

Positive Correlations (FDR = 0.029053)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1102 58.9383 9.09611 3830
Fornix_R 567 56.1865 7.41913 2429
Thalamic_Radiation_Superior_L 46 54.7424 4.20159 759
Corpus_Callosum_Tapetum 15 53.8882 2.81759 336
Cingulum_Frontal_Parietal_L 14 56.0045 2.65475 310
Corpus_Callosum_Forceps_Major 10 52.4029 2.5802 274



Negative Correlations (FDR = 1.0000)

Not significant



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop degree error rad3


Glass Brain displaying tracts that had MD positively correlated with loop degree error rad3







Men

Positive Correlations Not significant (FDR = 0.667369)

Not significant



Negative Correlations (FDR = 1.0000)

Not significant







Women

Positive Correlations (FDR = 0.065079)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 782 57.1293 9.88915 4388
Fornix_R 377 54.5825 7.47449 2395
Corpus_Callosum_Tapetum 97 53.9487 6.17569 1616
Corpus_Callosum_Forceps_Major 74 55.1716 5.46678 1295
Thalamic_Radiation_Superior_L 33 54.9695 4.13169 737
Cerebellum_R 10 52.5984 2.47474 253



Negative Correlations (FDR = 0.004739)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 90 53.6326 5.23412 1154



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop degree error rad3 in women


Glass Brain displaying tracts that had MD positively correlated with loop degree error rad3 in women







pre

Positive Correlations (FDR = 0.146316)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 505 60.2471 8.31941 3275
Fornix_R 166 56.7425 6.62161 1954
Corpus_Callosum_Forceps_Major 145 58.0109 6.7404 2070
Cerebellum_R 82 53.2532 6.52184 1779
Corpus_Callosum_Tapetum 22 53.2703 3.84954 620
Thalamic_Radiation_Superior_R 19 57.4829 2.87435 373
Thalamic_Radiation_Superior_L 18 55.0084 2.96573 380
Optic_Radiation_L 16 53.2582 3.23962 439



Negative Correlations (FDR = 1.000000)

Not significant



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop degree error rad3 in pre menopausal women


Glass Brain displaying tracts that had MD positively correlated with loop degree error rad3in pre menopausal women







peri

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.022007)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 194 61.4 11.9713 6911
Cerebellum_R 166 55.5612 11.441 5712
Corpus_Callosum_Tapetum 158 61.2292 11.7753 6668
Corpus_Callosum_Body 148 60.4303 11.4441 6216
Cerebellum_L 96 54.0528 8.28781 2916
Inferior_Longitudinal_Fasciculus_R 79 61.2021 8.94492 3846
Corticostriatal_Tract_Posterior_R 64 57.8857 7.99773 2908
Corpus_Callosum_Forceps_Minor 52 56.631 7.77975 2692
Arcuate_Fasciculus_R 50 60.8534 6.40874 1963
Arcuate_Fasciculus_L 48 55.8042 6.05898 1609
Fornix_L 43 61.1201 6.61413 2100
Inferior_Longitudinal_Fasciculus_L 33 63.2857 5.84826 1700
Inferior_Fronto_Occipital_Fasciculus_R 28 58.7835 5.69808 1499
Superior_Longitudinal_Fasciculus2_R 23 55.6632 5.31501 1235
Inferior_Fronto_Occipital_Fasciculus_L 22 63.9277 5.17381 1344
Middle_Cerebellar_Peduncle 20 58.6076 4.07403 764
Superior_Longitudinal_Fasciculus2_L 16 59.0182 4.25952 841
Uncinate_Fasciculus_R 15 54.5316 3.91366 656
Thalamic_Radiation_Posterior_L 15 54.1366 4.57 888
Dentatorubrothalamic_Tract_R 15 60.5337 3.83712 700
Dentatorubrothalamic_Tract_L 14 55.0038 4.26007 784
Parietal_Aslant_Tract_R 13 54.7754 3.69072 586
Superior_Longitudinal_Fasciculus1_R 13 55.5367 3.46602 524
Anterior_Commissure 13 62.9288 3.5016 606
Cingulum_Parahippocampal_Parietal_R 12 56.8391 3.73273 622
Corticostriatal_Tract_Posterior_L 12 59.1718 4.136 795
Thalamic_Radiation_Posterior_R 12 55.3345 4.13199 742
Medial_Lemniscus_R 12 57.169 3.92012 690
Optic_Radiation_L 12 54.0063 4.10569 715
Cingulum_Frontal_Parietal_L 11 61.0874 3.11319 465
Thalamic_Radiation_Superior_L 10 58.0198 3.52432 566
Medial_Lemniscus_L 10 53.2275 2.90586 353



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop degree error rad3 in peri menopausal women


Glass Brain displaying tracts that had MD negatively correlated with loop degree error rad3 in peri menopausal women







post

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.028408)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 271 63.5699 12.1455 7365
Cerebellum_R 239 55.9171 13.8456 8419
Corpus_Callosum_Tapetum 178 68.0098 10.8689 6310
Inferior_Longitudinal_Fasciculus_R 162 60.0737 10.9343 5641
Cerebellum_L 130 54.5338 10.3442 4583
Arcuate_Fasciculus_L 128 61.9484 8.91627 3868
Inferior_Longitudinal_Fasciculus_L 118 64.3014 9.33195 4398
Corpus_Callosum_Body 78 59.3181 9.07404 3836
Middle_Cerebellar_Peduncle 76 59.1945 7.22519 2427
Inferior_Fronto_Occipital_Fasciculus_R 64 57.2883 8.00052 2880
Corticostriatal_Tract_Posterior_R 61 58.0751 7.12573 2316
Fornix_L 59 56.6878 5.95527 1579
Superior_Longitudinal_Fasciculus2_L 50 57.37 6.91891 2157
Corpus_Callosum_Forceps_Minor 47 59.7577 7.00039 2300
Corticostriatal_Tract_Posterior_L 43 63.1306 6.58191 2148
Arcuate_Fasciculus_R 40 65.0155 5.58891 1595
Fornix_R 26 60.9299 3.0869 456
Thalamic_Radiation_Posterior_L 25 56.0088 5.56845 1364
Inferior_Fronto_Occipital_Fasciculus_L 24 57.7535 5.11123 1185
Thalamic_Radiation_Posterior_R 20 58.1078 4.73683 1024
Medial_Lemniscus_R 19 63.3737 4.77738 1136
Cingulum_Parahippocampal_Parietal_R 18 53.5647 3.94581 655
Frontal_Aslant_Tract_L 18 66.0046 4.29659 957
Dentatorubrothalamic_Tract_L 18 62.8991 4.39217 953
Superior_Longitudinal_Fasciculus2_R 17 58.352 4.61715 977
Corticostriatal_Tract_Anterior_L 17 55.0693 4.52603 886
Thalamic_Radiation_Superior_L 17 58.6989 3.49147 562
Dentatorubrothalamic_Tract_R 15 55.4647 3.62364 572
Optic_Radiation_L 14 54.8497 3.94371 670
Corticopontine_Tract_Parietal_L 13 56.6231 3.80836 645
Middle_Longitudinal_Fasciculus_R 12 70.0286 3.65064 733
Parietal_Aslant_Tract_L 12 58.5243 3.10798 444
Corticopontine_Tract_Parietal_R 11 59.6601 3.82348 685
Corticospinal_Tract_R 11 59.2704 3.39327 536
Thalamic_Radiation_Anterior_R 11 60.724 3.59681 617
Reticular_Tract_L 11 59.0983 3.5166 574



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop degree error rad3 in post menopausal women


Glass Brain displaying tracts that had MD positively and negatively correlated with loop degree error rad3 in post menopausal women







Peri + Post

Positive Correlations (FDR = 0.150602)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 427 57.6254 7.42329 2494
Corpus_Callosum_Tapetum 215 58.5033 6.48606 1933
Fornix_R 137 54.1106 4.96349 1047
Cerebellum_R 105 52.9458 6.3201 1661
Thalamic_Radiation_Superior_L 38 57.1603 3.75796 634
Cerebellum_L 18 53.1184 3.08092 396
Cingulum_Frontal_Parietal_L 10 55.4036 2.20205 211



Negative Correlations (FDR = 0.219578)

Not significant



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop degree error rad3


Glass Brain displaying tracts that had MD positively and negatively correlated with loop degree error rad3







RD

Summary







All subjects

Positive Correlations (FDR = 0.027027)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1110 58.9889 8.94864 3710
Fornix_R 617 56.7757 7.61385 2585
Thalamic_Radiation_Superior_L 45 54.9321 4.31151 802
Corpus_Callosum_Tapetum 15 53.8925 2.05069 178



Negative Correlations (FDR = 1.000000)

No Significant Findings

Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop degree error rad3


Glass Brain displaying tracts that had RD positively correlated with loop degree error rad3







Men

Positive Correlations (Not Significant?) (FDR = 0.553308)

No Significant Findings



Negative Correlations (FDR = 1.000000)

No Significant Findings







Women

Positive Correlations (FDR = 0.105231)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1372 57.8165 11.0265 5521
Fornix_R 540 55.0571 7.97616 2751
Corpus_Callosum_Tapetum 211 54.3779 8.80488 3311
Corpus_Callosum_Forceps_Major 150 55.5525 6.92112 2090
Thalamic_Radiation_Superior_L 77 57.1464 6.0171 1625
Cingulum_Frontal_Parietal_L 72 59.101 4.15148 800
Cingulum_Frontal_Parahippocampal_L 32 64.3257 4.19954 891
Thalamic_Radiation_Anterior_L 29 54.632 2.81081 339
Cerebellum_R 12 52.0263 3.03748 377
Optic_Radiation_L 11 52.0002 2.79478 319



Negative Correlations (FDR = 0.063559)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 122 53.923 5.61026 1333
Corpus_Callosum_Forceps_Minor 74 53.0905 4.93378 1015
Fornix_R 20 52.7018 3.25668 439
Middle_Longitudinal_Fasciculus_R 16 53.6393 2.97555 373
Cerebellum_L 10 52.4046 2.91611 350



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop degree error rad3 in women


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop degree error rad3 in women


Glass Brain displaying tracts that had RD positively and negatively correlated with loop degree error rad3 in women







pre

Positive Correlations (FDR = 0.181320))
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 989 61.09 9.76805 4578
Fornix_R 571 57.3213 8.97575 3627
Corpus_Callosum_Forceps_Major 235 58.5446 7.50519 2590
Cerebellum_R 93 53.3626 7.02275 2067
Corpus_Callosum_Tapetum 87 56.3269 7.01175 2175
Thalamic_Radiation_Superior_L 35 54.9227 4.50127 874
Corpus_Callosum_Body 24 55.5858 4.50749 887
Cerebellum_L 18 52.575 3.40946 480
Thalamic_Radiation_Superior_R 12 52.4981 3.51352 509
Optic_Radiation_L 10 53.0064 2.64839 292



Negative Correlations (FDR = 1.000000)

No Significant Findings



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop degree error rad3 in pre menopausal women


Glass Brain displaying tracts that had RD positively correlated with loop degree error rad3 in pre menopausal women







peri

Positive Correlations (FDR = 1.000000)

No Significant Findings



Negative Correlations (FDR = 0.020058)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 127 59.3316 9.53208 4234
Corpus_Callosum_Body 82 58.9622 9.06215 3803
Cerebellum_R 73 54.7961 8.60945 3190
Corpus_Callosum_Tapetum 67 58.7512 8.14476 3061
Cerebellum_L 52 53.3141 6.92838 2010
Corpus_Callosum_Forceps_Minor 43 57.3209 6.63849 1984
Inferior_Longitudinal_Fasciculus_R 19 61.0702 4.62051 1024
Fornix_L 18 62.2422 4.79508 1124
Corticostriatal_Tract_Posterior_R 17 53.4248 4.72556 937
Arcuate_Fasciculus_R 15 56.2796 4.06666 731
Thalamic_Radiation_Posterior_R 15 55.2023 4.38591 834
Middle_Cerebellar_Peduncle 15 58.9334 3.8103 672
Cingulum_Frontal_Parietal_L 14 58.3098 3.96507 720
Cingulum_Parolfactory_R 14 61.7313 2.47503 297
Superior_Longitudinal_Fasciculus2_R 13 62.4769 3.6647 659
Superior_Longitudinal_Fasciculus1_R 11 56.3646 3.22702 461



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop degree error rad3 in peri menopausal women


Glass Brain displaying tracts that had RD positively and negatively correlated with loop degree error rad3 in peri menopausal women







post

Positive Correlations (FDR = 1.000000)
No Significant Findings



Negative Correlations (FDR = 0.035618)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 230 64.1165 11.9657 7210
Cerebellum_R 225 55.4225 13.7812 8267
Corpus_Callosum_Body 183 61.5238 12.5668 7631
Corpus_Callosum_Tapetum 177 64.4304 11.564 6767
Inferior_Longitudinal_Fasciculus_L 114 66.4855 8.63665 3895
Arcuate_Fasciculus_L 112 62.3151 8.82772 3814
Cerebellum_L 110 55.3264 9.84773 4214
Corpus_Callosum_Forceps_Minor 96 57.4237 9.52411 4091
Inferior_Longitudinal_Fasciculus_R 88 59.9403 9.39353 4154
Fornix_L 86 58.1021 6.69104 2043
Middle_Cerebellar_Peduncle 84 59.0963 8.0637 3018
Inferior_Fronto_Occipital_Fasciculus_R 49 56.5742 7.2352 2326
Dentatorubrothalamic_Tract_R 48 62.4294 6.40263 2010
Corticostriatal_Tract_Posterior_L 46 64.4861 6.68295 2262
Corticostriatal_Tract_Posterior_R 45 57.4733 6.5473 1935
Cingulum_Frontal_Parietal_R 38 62.6973 5.57048 1528
Superior_Longitudinal_Fasciculus2_L 38 57.009 6.09255 1662
Dentatorubrothalamic_Tract_L 32 59.3868 6.27232 1835
Arcuate_Fasciculus_R 30 59.2057 5.85854 1596
Corticopontine_Tract_Parietal_L 29 65.2493 5.13636 1352
Thalamic_Radiation_Posterior_R 28 57.9266 5.26052 1259
Thalamic_Radiation_Posterior_L 27 58.3791 5.1456 1214
Medial_Lemniscus_L 26 57.4663 4.75621 1021
Medial_Lemniscus_R 26 62.2409 4.76303 1109
Inferior_Fronto_Occipital_Fasciculus_L 25 61.8548 5.38738 1410
Fornix_R 24 57.8261 3.16518 455
Frontal_Aslant_Tract_L 22 63.0986 4.78568 1135
Corticospinal_Tract_R 20 61.2025 4.17534 838
Superior_Longitudinal_Fasciculus2_R 19 58.7469 4.38455 887
Cingulum_Parolfactory_R 14 70.862 3.07719 527
Parietal_Aslant_Tract_L 14 61.7206 3.68708 659
Corticostriatal_Tract_Superior_R 14 51.5776 4.43561 797
Cingulum_Parahippocampal_Parietal_R 13 57.8576 3.72049 629
Corticostriatal_Tract_Anterior_R 13 52.7697 4.21979 738
Cingulum_Frontal_Parietal_L 12 56.1824 3.60042 572
Parietal_Aslant_Tract_R 12 55.5208 3.71248 601
Thalamic_Radiation_Superior_L 12 66.1783 3.39194 598
Extreme_Capsule_L 11 62.5425 3.59546 635
Extreme_Capsule_R 11 57.0932 3.76313 635
Middle_Longitudinal_Fasciculus_L 11 65.6455 3.85197 765
Middle_Longitudinal_Fasciculus_R 11 61.4663 3.55177 609
Corticopontine_Tract_Parietal_R 11 58.5549 3.40437 533
Thalamic_Radiation_Anterior_R 11 57.6448 3.79197 651
Reticular_Tract_L 11 54.5581 3.58267 550
Superior_Longitudinal_Fasciculus1_R 10 59.8195 3.4923 573
Corticospinal_Tract_L 10 56.1934 3.15747 440
Thalamic_Radiation_Anterior_L 10 53.8025 3.73029 588



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop degree error rad3 in post menopausal women


Glass Brain displaying tracts that had RD negatively correlated with loop degree error rad3 in women







Peri + Post

Positive Correlations (FDR = 0.141074)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 347 58.0147 7.10013 2297
Corpus_Callosum_Tapetum 200 57.9615 6.34724 1834
Cerebellum_R 86 52.5709 5.98706 1480
Fornix_R 77 54.5797 4.64526 925
Cerebellum_L 29 54.0811 4.28254 779
Thalamic_Radiation_Superior_L 24 55.8395 3.42013 513
Cingulum_Frontal_Parietal_L 13 59.8421 2.77528 362
Cingulum_Frontal_Parahippocampal_L 12 64.8506 3.05704 476
Inferior_Fronto_Occipital_Fasciculus_L 12 52.5052 2.7285 307



Negative Correlations (FDR = 0.240841)
No Significant Findings



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop degree error rad3 in women


Glass Brain displaying tracts that had RD positively and negatively correlated with loop degree error rad3 in women







Loop Degrees traveled average

QA

All subjects

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Superior_Longitudinal_Fasciculus2_R 32 55.5625 3.82062 637
Arcuate_Fasciculus_R 12 57.3333 2.65327 317



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 591 58.8494 10.5966 5190
Corpus_Callosum_Tapetum 544 54.6103 12.1484 6330
Corpus_Callosum_Body 464 54.7371 12.011 6202
Middle_Cerebellar_Peduncle 349 54.2006 8.78859 3288
Fornix_L 260 56.1615 6.20629 1699
Fornix_R 134 54.806 5.05519 1100
Cingulum_Frontal_Parietal_R 129 59.4729 5.89642 1624
Cerebellum_L 98 54.5714 6.21212 1654
Optic_Radiation_L 84 53 4.90382 1001
Inferior_Fronto_Occipital_Fasciculus_L 77 53.5584 4.84886 989
Cingulum_Parolfactory_R 26 56.5385 3.41545 518
Anterior_Commissure 22 53.1818 3.54192 524
Inferior_Longitudinal_Fasciculus_L 16 51.625 3.19926 415



Figures









Men

Positive Correlations (FDR =)

Not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 986 61.5396 11.7359 6657
Cerebellum_L 596 56.0403 13.6668 8221
Corpus_Callosum_Forceps_Minor 495 55.3616 11.1007 5358
Corpus_Callosum_Tapetum 450 54.6222 11.3956 5571
Corpus_Callosum_Body 406 57.8177 11.8085 6332
Fornix_L 114 65.6842 5.88719 1788
Fornix_R 95 56.7158 4.60107 943
Cerebellum_R 59 54.4407 6.49008 1801
Corticopontine_Tract_Parietal_R 57 56.7018 5.12566 1170
Middle_Cerebellar_Peduncle 51 57.2941 6.32992 1803
Vermis 48 53.7083 5.13667 1113
Optic_Radiation_L 42 53.8095 4.21827 752
Medial_Lemniscus_L 28 53.7857 4.44595 835
Corticospinal_Tract_L 27 53.4815 4.38047 806
Medial_Lemniscus_R 25 55.68 4.81056 1012
Corticospinal_Tract_R 18 53.8889 3.55203 534
Thalamic_Radiation_Superior_L 18 61.4444 2.93956 417
Corticopontine_Tract_Parietal_L 16 54.25 3.22082 442
Inferior_Fronto_Occipital_Fasciculus_L 15 52.9333 3.39082 478
Cingulum_Frontal_Parietal_R 13 54.9231 2.83215 346



Figures









Women

Positive Correlations (FDR =)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 1781 57.6261 15.4868 10855
Uncinate_Fasciculus_R 367 57.5695 8.22793 3061
Inferior_Fronto_Occipital_Fasciculus_R 277 57.1119 7.76561 2705
Cingulum_Frontal_Parietal_R 110 56.4727 6.27419 1746
Superior_Longitudinal_Fasciculus2_R 99 55.4545 5.80563 1468
Arcuate_Fasciculus_R 81 59.8519 5.67705 1515
Cingulum_Frontal_Parahippocampal_R 64 58.8438 4.33376 868
Uncinate_Fasciculus_L 23 52.8696 2.85728 339
Reticular_Tract_R 22 56.0909 3.48812 536
Dentatorubrothalamic_Tract_R 17 55.4118 2.67322 311
Corticostriatal_Tract_Anterior_L 15 52.1333 3.37719 467
Inferior_Fronto_Occipital_Fasciculus_L 11 52.3636 2.78943 320
Thalamic_Radiation_Anterior_R 11 52.9091 3.08701 396
Cingulum_Parolfactory_R 10 58.6 2.64505 322



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 638 55.3824 12.3813 6668
Corpus_Callosum_Body 627 57.1547 12.6972 7237
Corpus_Callosum_Forceps_Major 425 57.2471 9.0174 3656
Cerebellum_L 182 53.7582 7.73174 2524
Inferior_Longitudinal_Fasciculus_L 60 53.5667 5.66257 1349
Fornix_L 36 53.1667 3.27182 447
Medial_Lemniscus_R 31 59.3548 4.4785 935
Corticospinal_Tract_R 23 53.3043 2.97688 371
Inferior_Fronto_Occipital_Fasciculus_L 19 54.5263 3.72117 593
Corticopontine_Tract_Parietal_R 15 57.8667 3.97469 718
Optic_Radiation_L 15 52 2.95242 356
Corticostriatal_Tract_Superior_R 14 53.2857 3.52155 519
Arcuate_Fasciculus_L 13 53.0769 2.87264 344
Anterior_Commissure 10 52 2.76395 312



Figures









pre

Positive Correlations (FDR =)

Not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 173 56.4162 8.24344 3011
Cerebellum_L 106 54.3585 6.54707 1830
Corpus_Callosum_Forceps_Major 105 60.5714 5.92842 1672
Corpus_Callosum_Body 59 57.3898 5.32688 1279
Fornix_L 27 55.4815 3.7963 628



Figures









peri

Positive Correlations (FDR = )

Not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 559 65.0483 17.8225 16228
Cerebellum_L 348 55.3851 15.2739 10148
Cerebellum_R 256 54.3672 14.1032 8493
Corpus_Callosum_Forceps_Major 223 60.861 12.296 7227
Inferior_Fronto_Occipital_Fasciculus_R 200 61.66 11.1281 5997
Corpus_Callosum_Tapetum 194 62.3196 11.6815 6679
Middle_Cerebellar_Peduncle 170 61.0706 11.2819 6105
Superior_Longitudinal_Fasciculus2_R 149 62.8456 9.48224 4438
Arcuate_Fasciculus_R 137 67.2117 9.60105 4866
Corpus_Callosum_Forceps_Minor 135 60.6815 10.7786 5537
Arcuate_Fasciculus_L 130 58.9538 10.3301 4941
Inferior_Longitudinal_Fasciculus_R 110 59.7455 9.93758 4634
Inferior_Longitudinal_Fasciculus_L 108 62.0555 8.74352 3726
Corticospinal_Tract_L 108 61.037 9.40129 4237
Corticospinal_Tract_R 100 65.46 8.7018 3893
Cingulum_Frontal_Parietal_R 96 63.3958 7.3911 2720
Inferior_Fronto_Occipital_Fasciculus_L 94 62.766 8.63537 3676
Superior_Longitudinal_Fasciculus2_L 83 60.0482 8.85141 3695
Frontal_Aslant_Tract_L 78 61.2051 8.36793 3366
Corticostriatal_Tract_Posterior_R 72 64.9444 8.19435 3425
Dentatorubrothalamic_Tract_L 69 57.1304 8.85838 3521
Corticostriatal_Tract_Posterior_L 67 62.3284 8.44113 3488
Cingulum_Frontal_Parietal_L 66 60.2424 6.64466 2089
Dentatorubrothalamic_Tract_R 64 59.2188 8.16933 3104
Corticostriatal_Tract_Superior_L 61 55.9344 7.85127 2708
Medial_Lemniscus_L 59 58.2373 6.64554 2020
Medial_Lemniscus_R 50 61.88 6.48515 2044
Optic_Radiation_L 46 54.9565 5.65643 1381
Thalamic_Radiation_Posterior_R 40 62.15 6.14131 1841
Cingulum_Parahippocampal_Parietal_R 36 57.0556 5.36954 1292
Vermis 34 55 5.66033 1384
Cingulum_Parolfactory_R 31 63.5484 4.3971 965
Corticopontine_Tract_Parietal_R 30 63.6667 5.65665 1600
Corticostriatal_Tract_Superior_R 30 57.6667 5.93063 1593
Extreme_Capsule_L 28 58.9286 4.99771 1156
Superior_Longitudinal_Fasciculus3_R 28 62.2857 5.05292 1249
Corticopontine_Tract_Parietal_L 27 67.6296 5.32298 1505
Anterior_Commissure 24 66.5 4.71071 1159
Thalamic_Radiation_Posterior_L 23 55.8261 5.53857 1345
Extreme_Capsule_R 22 58.1818 4.61443 973
Superior_Longitudinal_Fasciculus1_R 22 66.4545 4.72653 1166
Cingulum_Parolfactory_L 20 56.6 2.89668 373
Middle_Longitudinal_Fasciculus_R 19 56.5263 4.4471 878
Fornix_L 16 54.75 3.386 493
Superior_Longitudinal_Fasciculus3_L 15 57.2 4.13464 768
Thalamic_Radiation_Anterior_R 15 58.4 4.12114 779
Uncinate_Fasciculus_L 14 58.2857 3.32796 507
Fornix_R 13 71.0769 2.89234 467
Parietal_Aslant_Tract_L 12 53.8333 3.7545 596
Middle_Longitudinal_Fasciculus_L 11 55.4545 3.59215 562
Parietal_Aslant_Tract_R 11 54.9091 2.75364 327
Reticular_Tract_L 11 59.6364 3.94515 729
Reticular_Tract_R 11 52.5455 3.91333 632
Thalamic_Radiation_Superior_L 10 52.8 3.48621 504



Figures









post

Positive Correlations (FDR = )

Not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 1223 68.4922 23.8079 30491
Corpus_Callosum_Forceps_Major 779 76.611 15.8746 15163
Arcuate_Fasciculus_L 732 72.2322 14.6435 12165
Middle_Cerebellar_Peduncle 617 62.8298 16.5267 13478
Corpus_Callosum_Forceps_Minor 582 66.8866 15.5466 12697
Corpus_Callosum_Tapetum 418 66.2679 14.302 10646
Cerebellum_R 376 57.7766 15.8848 11450
Inferior_Fronto_Occipital_Fasciculus_L 278 71.813 11.4968 7455
Inferior_Longitudinal_Fasciculus_L 221 67.4118 11.1532 6586
Superior_Longitudinal_Fasciculus2_L 215 62.8837 11.7838 6858
Corticostriatal_Tract_Posterior_L 192 68.3854 10.6649 6109
Cerebellum_L 176 55.2955 12.4476 6729
Inferior_Fronto_Occipital_Fasciculus_R 159 65.0943 11.5269 6793
Corticospinal_Tract_R 157 63.1083 9.67544 4640
Corticostriatal_Tract_Posterior_R 137 58.2482 9.94212 4522
Superior_Longitudinal_Fasciculus2_R 128 61.1719 10.2473 5045
Extreme_Capsule_L 120 64.1167 8.6053 3729
Cingulum_Frontal_Parietal_L 108 67.7222 8.03858 3437
Medial_Lemniscus_L 107 61.8318 8.49679 3506
Inferior_Longitudinal_Fasciculus_R 104 59.6923 10.1185 4800
Corticospinal_Tract_L 96 63.0208 9.15886 4152
Dentatorubrothalamic_Tract_R 93 62.0645 9.42818 4333
Dentatorubrothalamic_Tract_L 86 64.093 9.35136 4402
Thalamic_Radiation_Posterior_L 84 61.2143 7.87029 2978
Parietal_Aslant_Tract_L 83 61.5181 6.86341 2276
Corticostriatal_Tract_Superior_L 79 59.5949 8.55547 3426
Medial_Lemniscus_R 77 61.3507 7.50638 2715
Arcuate_Fasciculus_R 72 58.0556 8.52529 3314
Middle_Longitudinal_Fasciculus_L 68 60.3235 7.06076 2362
Middle_Longitudinal_Fasciculus_R 67 67.0149 6.78914 2426
Thalamic_Radiation_Anterior_R 66 64 7.63091 2927
Corticostriatal_Tract_Superior_R 59 55.5593 7.95012 2758
Cingulum_Frontal_Parietal_R 40 60.25 5.9014 1648
Superior_Longitudinal_Fasciculus3_L 39 62.1538 5.75897 1619
Thalamic_Radiation_Superior_L 39 63.1282 6.89043 2354
Thalamic_Radiation_Superior_R 39 58.8205 6.25763 1809
Parietal_Aslant_Tract_R 36 57.7778 6.01169 1640
Superior_Longitudinal_Fasciculus1_L 36 62.5556 5.28829 1374
Thalamic_Radiation_Anterior_L 36 60.5 6.00596 1714
Cingulum_Parahippocampal_Parietal_L 33 57.2727 5.17147 1203
Extreme_Capsule_R 32 60.125 5.6604 1513
Reticular_Tract_L 32 58.9375 5.47193 1386
Frontal_Aslant_Tract_R 29 56.6207 5.70035 1445
Uncinate_Fasciculus_R 28 61.2143 4.67552 1051
Corticopontine_Tract_Parietal_L 28 63.8571 5.23983 1377
Frontal_Aslant_Tract_L 27 61.8519 6.14438 1834
Thalamic_Radiation_Posterior_R 26 63.3846 5.63546 1581
Fornix_L 23 54.5217 5.06835 1100
Corticostriatal_Tract_Anterior_L 20 55.6 4.78061 998
Corticostriatal_Tract_Anterior_R 20 54.6 5.13104 1129
Anterior_Commissure 20 58.4 5.09785 1192
Vermis 20 58 4.72964 1019
Cingulum_Frontal_Parahippocampal_L 19 67.5789 4.42868 1041
Cingulum_Parolfactory_L 19 58.9474 4.62891 992
Superior_Longitudinal_Fasciculus3_R 18 57.1111 4.70984 995
Uncinate_Fasciculus_L 18 55.8889 3.87467 659
Corticopontine_Tract_Parietal_R 18 62.3333 4.38652 942
Reticular_Tract_R 18 59.4444 4.96952 1153
Cingulum_Parolfactory_R 17 60.2353 3.62306 621
Inferior_Cerebellar_Peduncle_L 17 56.2353 4.1618 765
Fornix_R 16 61 3.95395 749
Optic_Radiation_L 15 55.8667 4.00842 705
Superior_Longitudinal_Fasciculus1_R 13 56.3077 4.1099 747
Inferior_Cerebellar_Peduncle_R 13 79.8461 4.08993 1049
Superior_Cerebellar_Peduncle 13 57.5385 3.59794 585
Corticopontine_Tract_Frontal_L 11 55.6364 3.91865 671
Cingulum_Parahippocampal_Parietal_R 10 53.2 3.45581 499



Figures









Peri Post

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 413 57.2397 11.1928 5632
Corpus_Callosum_Body 228 57.5175 10.6534 5127
Corticospinal_Tract_R 197 57.6751 6.83469 2116
Cingulum_Frontal_Parietal_R 159 57.7358 6.35269 1830
Cerebellum_R 46 53.5217 4.66297 914
Superior_Longitudinal_Fasciculus1_R 45 55.0667 4.03743 705
Middle_Cerebellar_Peduncle 43 55.0698 5.12041 1134
Corpus_Callosum_Forceps_Major 42 56.8095 5.58553 1392
Thalamic_Radiation_Anterior_R 40 58.9 3.82553 677
Cingulum_Frontal_Parahippocampal_R 37 55.7297 4.28321 803
Cingulum_Parolfactory_R 37 56.973 4.1858 784
Uncinate_Fasciculus_R 37 57.2973 4.13382 769
Medial_Lemniscus_R 37 57.7838 5.23555 1244
Inferior_Fronto_Occipital_Fasciculus_R 30 55.9333 4.01454 708
Corpus_Callosum_Tapetum 26 53.3846 4.66385 912
Anterior_Commissure 25 56.32 2.6086 301
Dentatorubrothalamic_Tract_R 12 55.1667 3.47098 522



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Arcuate_Fasciculus_L 277 58.8664 8.29735 3183
Corpus_Callosum_Tapetum 83 57.1566 6.83146 2095
Corpus_Callosum_Body 65 57.0462 6.57517 1937
Corpus_Callosum_Forceps_Major 64 59.75 6.32607 1878
Corticostriatal_Tract_Posterior_L 54 60.7037 5.77492 1590
Cingulum_Parolfactory_L 45 56.9333 2.4206 262
Inferior_Longitudinal_Fasciculus_L 35 59.1429 3.5214 576
Inferior_Fronto_Occipital_Fasciculus_L 29 56.8276 4.9509 1094
Cerebellum_L 22 52.3636 3.22221 427
Cerebellum_R 20 53.3 3.59825 542
Middle_Cerebellar_Peduncle 19 52.8421 3.62379 545
Optic_Radiation_L 17 56 2.94709 382
Superior_Longitudinal_Fasciculus2_R 16 52.25 2.77056 315
Parietal_Aslant_Tract_L 14 53.4286 3.27108 449
Superior_Longitudinal_Fasciculus2_L 10 54.2 2.37444 240



Figures









box plots

## 
## Call:
## lm(formula = loop_de_avg_degree ~ Fornix_L + sex, data = QA_df)
## 
## Residuals:
##      Min       1Q   Median       3Q      Max 
## -115.284  -29.571    1.033   18.107  130.971 
## 
## Coefficients:
##             Estimate Std. Error t value Pr(>|t|)    
## (Intercept)   466.24      36.02  12.942 1.07e-15 ***
## Fornix_L     -347.08     131.31  -2.643   0.0118 *  
## sexmale       -54.93      17.95  -3.059   0.0040 ** 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## Residual standard error: 52.9 on 39 degrees of freedom
## Multiple R-squared:  0.2345, Adjusted R-squared:  0.1953 
## F-statistic: 5.974 on 2 and 39 DF,  p-value: 0.005454
## quartz_off_screen 
##                 2

MD

All subjects

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 686 60.3003 7.41793 2606
Fornix_R 265 57.5321 5.14692 1197
Thalamic_Radiation_Superior_L 95 57.6421 3.94341 704
Thalamic_Radiation_Superior_R 14 60.2857 2.03977 197



Negative Correlations (FDR = )

Not significant



Figures









Men

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 968 58.0764 8.61077 3382
Fornix_L 753 60.494 9.28153 4093
Thalamic_Radiation_Superior_L 28 55.5714 4.08128 727
Cerebellum_L 23 54.6087 3.34189 479
Corpus_Callosum_Forceps_Major 17 54.2353 3.30755 466



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 31 54.3871 4.02785 693



Figures









Women

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 699 56.5637 9.25473 3805
Fornix_R 430 55.0233 6.98587 2109
Thalamic_Radiation_Superior_L 25 59.84 3.1958 480



Negative Correlations (FDR = )

not significant



Figures









pre

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 861 58.7154 9.33202 4016
Fornix_R 246 55.935 6.53825 1878
Corpus_Callosum_Forceps_Major 147 60.068 6.45379 1965
Corpus_Callosum_Tapetum 42 56.2381 4.79136 1014
Cerebellum_R 34 52.2941 4.81698 953
Thalamic_Radiation_Superior_L 31 53.1613 3.66881 562



Negative Correlations (FDR = )

not significant



Figures









peri

Positive Correlations (FDR = )

not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 132 61.0909 10.0974 4892
Corpus_Callosum_Tapetum 98 61.2041 8.63473 3584
Corpus_Callosum_Body 80 63.65 7.72342 2982
Cerebellum_R 80 54.75 7.92401 2700
Corticostriatal_Tract_Posterior_R 63 56.2222 6.9908 2158
Inferior_Longitudinal_Fasciculus_R 59 62.1017 7.40153 2672
Cerebellum_L 49 53.1837 6.29265 1654
Fornix_L 38 63.4737 5.54716 1534
Corpus_Callosum_Forceps_Minor 35 58.6286 6.12593 1728
Arcuate_Fasciculus_R 30 58.2 5.08513 1182
Inferior_Fronto_Occipital_Fasciculus_R 23 58.7826 4.67031 1007
Inferior_Fronto_Occipital_Fasciculus_L 21 62.8571 4.42121 965
Arcuate_Fasciculus_L 20 55.4 4.42766 853
Inferior_Longitudinal_Fasciculus_L 17 59.2941 4.15764 805
Anterior_Commissure 16 58 3.67433 615
Middle_Cerebellar_Peduncle 12 63.6667 3.6358 661
Cingulum_Frontal_Parietal_L 11 60.1818 3.17341 476
Dentatorubrothalamic_Tract_L 11 56.1818 3.36285 499
Dentatorubrothalamic_Tract_R 11 60 3.15139 468
Reticular_Tract_L 11 63.6364 2.81837 397
Superior_Longitudinal_Fasciculus2_L 10 59.6 3.19221 477
Superior_Longitudinal_Fasciculus2_R 10 56 3.57143 561
Optic_Radiation_L 10 54.2 3.39276 490



Figures









post

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 279 55.9426 14.3399 9035
Corpus_Callosum_Forceps_Major 267 64.382 12.3208 7676
Corpus_Callosum_Tapetum 218 66.3394 11.4132 6787
Inferior_Longitudinal_Fasciculus_R 164 60.2195 10.9181 5638
Cerebellum_L 151 55.3642 10.6867 4966
Arcuate_Fasciculus_L 142 61.1268 9.0649 3945
Fornix_L 127 58.9291 6.78709 2132
Inferior_Longitudinal_Fasciculus_L 110 65.4364 8.87714 4050
Corpus_Callosum_Body 91 58.5494 9.45168 4108
Corticostriatal_Tract_Posterior_R 71 58.2817 7.57852 2629
Middle_Cerebellar_Peduncle 70 61.9714 7.02938 2405
Inferior_Fronto_Occipital_Fasciculus_R 67 57.4328 7.99461 2883
Arcuate_Fasciculus_R 54 63.8889 6.31647 2002
Superior_Longitudinal_Fasciculus2_L 53 57.2075 7.09536 2262
Corpus_Callosum_Forceps_Minor 49 59.3469 7.09144 2344
Corticostriatal_Tract_Posterior_L 42 62.9524 6.47357 2072
Fornix_R 39 59.7949 3.65681 628
Superior_Longitudinal_Fasciculus2_R 33 61.4545 5.73412 1587
Inferior_Fronto_Occipital_Fasciculus_L 31 57.2258 5.53712 1378
Thalamic_Radiation_Superior_L 29 58.4138 4.21738 816
Thalamic_Radiation_Posterior_L 26 55.8461 5.61322 1382
Frontal_Aslant_Tract_L 22 65.7273 4.45816 1026
Dentatorubrothalamic_Tract_L 21 67.8095 4.30059 985
Thalamic_Radiation_Posterior_R 19 58.6316 4.51326 938
Dentatorubrothalamic_Tract_R 19 55.1579 4.18022 757
Medial_Lemniscus_R 19 63.0526 4.67862 1084
Corticostriatal_Tract_Anterior_L 18 55.1111 4.65518 938
Corticopontine_Tract_Parietal_R 17 59.1765 4.10451 783
Corticospinal_Tract_R 17 58.5882 3.53495 575
Cingulum_Parahippocampal_Parietal_R 16 54.375 3.80408 618
Middle_Longitudinal_Fasciculus_R 15 66.4 3.86739 780
Corticostriatal_Tract_Anterior_R 14 54 4.20522 750
Corticopontine_Tract_Parietal_L 13 56.1538 3.95539 690
Reticular_Tract_L 13 58.7692 3.80993 670
Thalamic_Radiation_Anterior_R 12 59.1667 3.71982 643
Optic_Radiation_L 12 55.3333 3.86442 649
Extreme_Capsule_L 11 56.9091 2.91579 380
Extreme_Capsule_R 11 54.1818 3.95311 665
Parietal_Aslant_Tract_L 11 59.2727 3.0215 425
Medial_Lemniscus_L 11 60 3.2015 483
Anterior_Commissure 11 54 3.65314 566
Thalamic_Radiation_Anterior_L 10 56.4 3.8277 649
Inferior_Cerebellar_Peduncle_L 10 58.6 2.62029 316



Negative Correlations (FDR = )

not significant



Figures









peri post

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 699 56.5637 9.25473 3805
Fornix_R 430 55.0233 6.98587 2109
Thalamic_Radiation_Superior_L 25 59.84 3.1958 480



Negative Correlations (FDR = )

not significant



Figures









box plots

AD

All subjects

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1263 57.5994 9.67549 4235
Fornix_R 652 55.7025 7.94709 2763
Thalamic_Radiation_Superior_L 119 56.1513 5.28543 1232
Thalamic_Radiation_Superior_R 12 57.1667 2.02988 185



Negative Correlations (FDR = )

Not significant



Figures









Men

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 1141 56.3401 9.41456 3922
Fornix_L 539 58.8646 8.75538 3544
Thalamic_Radiation_Superior_L 34 54.4706 4.37271 818
Cerebellum_L 23 53.5652 3.1218 410



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 49 52.9388 4.71416 924
Cerebellum_L 13 51.2308 2.56633 265



Figures









Women

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 926 55.7365 10.1355 4497
Fornix_R 661 54.6596 7.84788 2644
Thalamic_Radiation_Superior_L 125 58.336 5.8145 1549
Cingulum_Frontal_Parietal_L 55 57.7091 3.48349 550
Corpus_Callosum_Forceps_Major 19 54.8421 2.85057 350
Thalamic_Radiation_Anterior_L 17 58.8235 2.13708 211
Cingulum_Frontal_Parahippocampal_L 16 59.875 2.68492 339



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 40 53.75 4.24579 761



Figures









pre

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1252 57.1022 10.5101 4954
Fornix_R 568 55.7887 8.19553 2943
Corpus_Callosum_Forceps_Major 250 58.752 7.90846 2886
Corpus_Callosum_Tapetum 99 54.202 6.35456 1719
Thalamic_Radiation_Superior_L 90 55.6889 5.79143 1467
Cerebellum_R 90 53.3111 7.09042 2105
Corpus_Callosum_Forceps_Minor 44 51.8636 3.91082 623
Optic_Radiation_L 16 55.125 3.73198 603
Anterior_Commissure 13 57.2308 2.69308 326
Thalamic_Radiation_Superior_R 10 54 2.42789 250



Negative Correlations (FDR = )

Not significant



Figures









peri

Positive Correlations (FDR = )

not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 141 68.9362 9.39507 4779
Cerebellum_R 90 54.0667 8.52073 3083
Corpus_Callosum_Forceps_Major 73 63.5616 7.81385 3048
Cerebellum_L 65 54.1231 6.69088 1903
Corpus_Callosum_Body 44 59.6818 6.35491 1893
Fornix_L 36 61.6111 5.34803 1384
Inferior_Longitudinal_Fasciculus_L 32 56.5 5.20455 1202
Corticostriatal_Tract_Posterior_R 32 57.875 6.23135 1765
Middle_Cerebellar_Peduncle 25 55.12 4.76516 983
Arcuate_Fasciculus_R 24 66.1667 4.66929 1133
Inferior_Fronto_Occipital_Fasciculus_R 24 56.75 5.46874 1333
Inferior_Longitudinal_Fasciculus_R 21 58.4762 5.33258 1306
Corticospinal_Tract_R 21 63.0476 4.08176 825
Cingulum_Parolfactory_R 20 62.6 3.66664 661
Inferior_Fronto_Occipital_Fasciculus_L 20 59.2 4.71579 1034
Corticospinal_Tract_L 19 58.7368 4.18769 809
Dentatorubrothalamic_Tract_L 18 55.3333 4.08442 725
Arcuate_Fasciculus_L 17 59.1765 4.37598 890
Dentatorubrothalamic_Tract_R 14 60.7143 3.97381 753
Medial_Lemniscus_R 14 61.1429 3.23965 504
Middle_Longitudinal_Fasciculus_R 13 55.5385 3.63071 575
Superior_Longitudinal_Fasciculus2_L 13 55.5385 3.44273 517
Corticostriatal_Tract_Posterior_L 13 55.5385 3.7273 606
Thalamic_Radiation_Posterior_L 13 58 4.0332 741
Corticopontine_Tract_Parietal_L 12 61 2.91107 406
Optic_Radiation_L 11 58.5455 3.48046 557
Thalamic_Radiation_Anterior_R 10 53.6 3.0084 381



Figures









post

Positive Correlations (FDR = )

Not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 178 55.5393 11.7623 6035
Cerebellum_L 117 54.3077 9.54131 3883
Corpus_Callosum_Tapetum 82 58.2927 8.15399 3044
Fornix_L 58 59.3793 5.38426 1352
Corpus_Callosum_Forceps_Major 57 58.9474 6.60539 2020
Inferior_Longitudinal_Fasciculus_R 44 54 6.13059 1594
Fornix_R 32 59.8125 3.18987 478
Corticostriatal_Tract_Posterior_R 31 58.3871 5.80445 1545
Middle_Cerebellar_Peduncle 31 55.2903 5.96671 1546
Inferior_Fronto_Occipital_Fasciculus_R 27 53.1852 5.40873 1222
Arcuate_Fasciculus_L 24 54.3333 5.13678 1126
Thalamic_Radiation_Superior_L 18 60 3.24102 495
Inferior_Longitudinal_Fasciculus_L 16 57.625 3.6471 602
Cingulum_Parolfactory_R 14 54.4286 2.66673 304
Corpus_Callosum_Body 14 56.8571 4.1954 786
Corticostriatal_Tract_Superior_R 13 53.6923 2.55831 276
Arcuate_Fasciculus_R 11 56.5455 3.5857 571
Corticospinal_Tract_R 10 66.6 2.66321 371



Figures









Peri and Post

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 179 54.0782 6.75319 1937
Fornix_R 158 53.4304 6.09905 1561
Cerebellum_R 64 54.875 3.97796 682
Cerebellum_L 31 54.4516 3.83813 630
Thalamic_Radiation_Superior_L 26 59.2308 3.48502 565
Corpus_Callosum_Tapetum 13 55.2308 2.94414 376



Negative Correlations (FDR = )

not Significant



Figures









RD

All subjects

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 756 60.1772 7.6625 2775
Fornix_R 276 57.8768 4.86981 1078
Thalamic_Radiation_Superior_L 70 57.2857 3.83004 660
Cingulum_Frontal_Parietal_L 10 54 2.09418 186



Negative Correlations (FDR = )

Not significant



Figures









Men

Positive Correlations (FDR = )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 1027 58.6115 8.67592 3465
Fornix_L 821 60.5944 9.7294 4505
Corpus_Callosum_Forceps_Major 25 55.6 3.72831 607
Thalamic_Radiation_Superior_L 24 55.8333 3.99252 699
Cerebellum_L 19 53.6842 2.99022 377



Negative Correlations (FDR = )



Figures









Women

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1217 57.7469 10.1179 4643
Fornix_R 649 55.8835 7.81122 2678
Thalamic_Radiation_Superior_L 38 55.8497 5.02364 1107
Corpus_Callosum_Tapetum 22 53.0118 4.20729 737
Cingulum_Frontal_Parahippocampal_L 19 67.0623 3.53451 658
Corpus_Callosum_Forceps_Major 12 53.5152 3.06171 394



Negative Correlations (FDR = )



Figures









pre

Positive Correlations (FDR = )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 977 59.1279 9.64608 4321
Fornix_R 337 56.2552 7.34097 2381
Corpus_Callosum_Forceps_Major 142 58.493 6.36981 1864
Corpus_Callosum_Tapetum 37 55.3513 4.90286 1045
Thalamic_Radiation_Superior_L 21 56.381 3.09801 425
Cerebellum_R 12 52 2.8079 322
Corpus_Callosum_Body 10 54.2 3.38236 487



Negative Correlations (FDR = )



Figures









peri

Positive Correlations (FDR = )

not significant

Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 147 58.6122 9.62431 4264
Corpus_Callosum_Body 111 58.991 9.24623 3961
Corpus_Callosum_Tapetum 77 59.9481 8.30569 3248
Cerebellum_R 70 54.2857 7.64516 2492
Cerebellum_L 45 53.3333 6.64571 1850
Corpus_Callosum_Forceps_Minor 42 59.1429 6.5601 1999
Fornix_L 35 63.3714 5.46776 1488
Inferior_Longitudinal_Fasciculus_R 22 60.1818 4.93469 1151
Corticostriatal_Tract_Posterior_R 22 53.3636 4.72827 937
Thalamic_Radiation_Posterior_R 17 55.0588 4.49055 872
Arcuate_Fasciculus_R 16 55.5 4.18654 764
Middle_Cerebellar_Peduncle 15 61.6 3.87109 725
Cingulum_Frontal_Parietal_L 12 59.3334 3.82278 681
Cingulum_Parolfactory_R 12 63.3333 2.40204 287
Superior_Longitudinal_Fasciculus2_R 11 62.3636 3.5058 602
Reticular_Tract_R 10 57.2 2.74699 339



Figures









post

Positive Correlations (FDR = )

Not significant



Negative Correlations (FDR = )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 271 65.107 11.967 7323
Cerebellum_R 261 55.3563 13.9362 8444
Corpus_Callosum_Tapetum 233 63.7597 12.0647 7289
Corpus_Callosum_Body 227 60.6696 13.0862 8160
Fornix_L 182 60.3077 7.41178 2602
Cerebellum_L 141 55.8723 10.5433 4878
Arcuate_Fasciculus_L 133 61.5038 9.17574 4067
Inferior_Longitudinal_Fasciculus_L 115 66.4174 8.59436 3853
Corpus_Callosum_Forceps_Minor 106 57.0566 9.73287 4245
Inferior_Longitudinal_Fasciculus_R 98 59.449 9.66442 4361
Middle_Cerebellar_Peduncle 88 59.7727 7.70499 2787
Inferior_Fronto_Occipital_Fasciculus_R 66 55.8485 7.37229 2384
Corticostriatal_Tract_Posterior_R 57 58 7.11647 2307
Dentatorubrothalamic_Tract_R 55 61.7454 6.86579 2286
Fornix_R 50 57.64 4.33823 852
Corticostriatal_Tract_Posterior_L 49 64.3673 6.68024 2256
Cingulum_Frontal_Parietal_R 43 61.5349 5.82527 1640
Superior_Longitudinal_Fasciculus2_L 38 57.2105 6.16179 1706
Dentatorubrothalamic_Tract_L 36 60.3889 6.38069 1931
Inferior_Fronto_Occipital_Fasciculus_L 33 62.5455 5.91555 1719
Corticopontine_Tract_Parietal_L 30 64.8 5.24483 1400
Arcuate_Fasciculus_R 29 59.1034 5.81565 1570
Superior_Longitudinal_Fasciculus2_R 29 60.2759 5.37363 1367
Corticospinal_Tract_R 29 60.2759 4.38193 909
Thalamic_Radiation_Posterior_R 29 58.1379 5.25095 1259
Thalamic_Radiation_Posterior_L 28 60.3571 5.19632 1280
Medial_Lemniscus_L 28 57.3571 4.87591 1071
Uncinate_Fasciculus_R 26 61.4615 3.48419 586
Frontal_Aslant_Tract_L 24 62.3333 4.95916 1204
Thalamic_Radiation_Superior_L 23 62.9565 3.9024 753
Medial_Lemniscus_R 23 63.1304 4.77814 1132
Parietal_Aslant_Tract_L 18 60.7778 4.20488 844
Cingulum_Parahippocampal_Parietal_R 17 56.7059 3.88152 671
Middle_Longitudinal_Fasciculus_R 17 58.4706 4.16073 795
Corticostriatal_Tract_Superior_R 17 51.2941 4.5717 842
Cingulum_Parolfactory_R 16 69.5 3.13945 538
Reticular_Tract_R 16 59.375 3.81582 679
Extreme_Capsule_R 15 56.8 4.10572 752
Parietal_Aslant_Tract_R 15 55.6 3.73138 608
Corticostriatal_Tract_Anterior_R 15 52.4 4.55531 854
Extreme_Capsule_L 14 60.1429 3.67514 638
Thalamic_Radiation_Anterior_L 14 53.1429 4.10403 703
Cingulum_Frontal_Parietal_L 13 58 3.83798 671
Reticular_Tract_L 13 54.7692 3.9701 678
Frontal_Aslant_Tract_R 12 55.1667 3.40722 503
Middle_Longitudinal_Fasciculus_L 12 64.3333 4.00387 810
Corticospinal_Tract_L 12 55.5 3.44059 516
Superior_Longitudinal_Fasciculus1_R 11 60.5455 3.45612 568
Thalamic_Radiation_Anterior_R 11 57.6364 3.76595 642
Corticopontine_Tract_Parietal_R 10 59.2 3.32164 513
Corticostriatal_Tract_Anterior_L 10 51.4 3.49105 492
Corticostriatal_Tract_Superior_L 10 54 3.84189 626
Optic_Radiation_L 10 54.2 2.89188 356
Inferior_Cerebellar_Peduncle_R 10 63.4 3.25632 528



Figures









Peri and Post

Positive Correlations (FDR = )

Not significant



Negative Correlations (FDR = )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 270 59.8593 9.96021 4664
Corpus_Callosum_Forceps_Major 252 58.5317 9.31285 3987
Corpus_Callosum_Body 187 59.7433 7.80444 2858
Cerebellum_R 177 55.5141 8.01225 2799
Fornix_L 96 56.9375 6.05958 1642
Fornix_R 80 56.625 4.72764 994
Inferior_Longitudinal_Fasciculus_R 57 55.4035 5.23608 1193
Cingulum_Frontal_Parietal_R 31 55.2258 4.33208 814
Superior_Longitudinal_Fasciculus2_R 31 54.9032 3.89444 654
Cingulum_Parolfactory_R 23 55.913 3.69019 598
Dentatorubrothalamic_Tract_R 20 55.4 3.43367 513
Inferior_Fronto_Occipital_Fasciculus_R 18 55.7778 3.34443 490
Corpus_Callosum_Forceps_Minor 18 54.6667 3.6115 560
Cingulum_Parahippocampal_Parietal_R 11 52 3.60579 531



Figures